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Adult Growth Hormone Insufficiency

Meaning

Adult Growth Hormone Insufficiency (AGHI) is a recognized clinical syndrome characterized by a deficiency in the secretion of pituitary growth hormone (GH) in patients who have reached full skeletal maturity. This endocrine disorder results in a spectrum of adverse changes in body composition, lipid metabolism, and overall quality of life. Diagnosis typically requires provocative testing to confirm the inadequate GH reserve, distinguishing it from the normal age-related decline in GH secretion. The resulting hormonal imbalance impacts multiple organ systems, underscoring the importance of precise endocrine evaluation.