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Adrenopause Pathophysiology

Meaning

Adrenopause Pathophysiology refers to the specific biological processes underlying the age-related decline in adrenal gland function, particularly the reduced production of dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S). This is not a disease state but a natural endocrinological transition often starting in the third decade of life. The clinical presentation involves a gradual shift in the body’s homeostatic balance, influencing energy, immunity, and overall metabolic health. Understanding this physiological shift is critical for effective hormonal health management and longevity strategies.