Clinical strategies aimed at mitigating the physiological and symptomatic consequences associated with the age-related decline in adrenal androgen production, specifically DHEA and DHEA-S. This comprehensive approach focuses on restoring a more youthful hormonal milieu to support vitality and metabolic function. Effective management seeks to address common symptoms like reduced energy, decreased libido, and changes in body composition linked to this endocrine shift. It represents a proactive intervention within the scope of hormonal health and longevity medicine.
Origin
The term “Adrenopause” is a clinical construct derived from “adrenal,” referring to the adrenal glands, and “pause,” signifying a cessation or decline, mirroring the concept of menopause or andropause. Management refers to the systematic application of therapeutic protocols to address this natural decline. The concept emerged from endocrinology research observing the consistent age-related reduction in adrenal steroidogenesis.
Mechanism
Management protocols often involve the careful, monitored replacement of dehydroepiandrosterone (DHEA) to restore circulating levels to a physiologic range. DHEA acts as a precursor to various sex hormones, influencing neurosteroid synthesis and modulating immune function. The mechanism of action involves the peripheral conversion of DHEA into androgens and estrogens, thereby supporting tissue health, bone density, and mood stability. This intervention seeks to restore balance to the hypothalamic-pituitary-adrenal (HPA) axis feedback loop.
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