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Adrenergic Receptor Upregulation

Meaning

Adrenergic Receptor Upregulation is a physiological process characterized by an increase in the number or sensitivity of adrenergic receptors on the surface of target cells. These receptors are primary targets for catecholamines, such as epinephrine and norepinephrine, which mediate the sympathetic nervous system’s effects. This upregulation leads to an enhanced cellular response to circulating catecholamines, effectively amplifying the body’s sensitivity to these vital stress and arousal hormones. Clinically, this can translate to heightened vigilance, increased metabolic rate, and a stronger cardiovascular response to sympathetic stimulation.