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Adrenal System Interplay

Meaning

The complex, bidirectional communication and functional relationship between the adrenal glands and other key physiological systems, notably the hypothalamic-pituitary-adrenal (HPA) axis. This interplay is central to maintaining homeostasis, especially in response to physical and psychological stressors. It defines how adrenal hormone output, such as cortisol and DHEA, is modulated and how these hormones subsequently influence metabolism, immune function, and neuroendocrine balance across the body.