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Adrenal Suppression Reversal

Meaning

The clinical process of restoring the endogenous production of cortisol and other essential adrenal hormones following a period where the hypothalamic-pituitary-adrenal (HPA) axis was suppressed, typically due to prolonged exogenous glucocorticoid administration. This restoration is a critical endocrinological objective necessary to prevent an adrenal crisis and ensure the body can adequately mount a physiological response to stress. The goal is to safely and strategically wean the individual off the suppressive agent while meticulously monitoring the HPA axis’s return to autonomous, self-regulating function.