Clinical assessment of the Hypothalamic-Pituitary-Adrenal (HPA) axis function, specifically evaluating cortisol dynamics under controlled physiological stress. This testing quantifies the capacity of the adrenal glands to mount an appropriate glucocorticoid response and subsequent recovery. It moves beyond static measurement to explore dynamic endocrine reserve.
Origin
Derived from endocrinology and stress physiology, the concept focuses on the body’s adaptive capacity to manage allostatic load. The term “resilience” here reflects the functional integrity required to maintain homeostasis despite chronic or acute stressors. It builds upon historical interpretations of adrenal fatigue models by focusing on measurable physiological output.
Mechanism
The process typically involves timed salivary or serum sampling following the administration of a synthetic corticotropin-releasing hormone analogue or a standardized psychological stressor. Analysis tracks the rise, peak, and decay phases of cortisol secretion patterns. Successful management relies on restoring normal feedback signaling between the hypothalamus, pituitary, and adrenal cortex.
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