What is the Origin of Adrenal Reserve Capacity Assessment?

Derived from the endocrinological need to evaluate the hypothalamic-pituitary-adrenal (HPA) axis function beyond basal measurements. The concept stems from stress physiology, linking adrenal gland viability to systemic adaptation capabilities. It represents an evolution from simple morning cortisol testing toward functional endocrinology. The terminology emphasizes 'capacity' as a measurable clinical parameter.

What is the Mechanism of Adrenal Reserve Capacity Assessment?

Typically involves administering a synthetic ACTH analogue, such as cosyntropin, to stimulate the adrenal cortex. Serum cortisol levels are then measured at predetermined intervals to map the secretory response curve. Analysis focuses on the magnitude and speed of the cortisol rise relative to baseline. Deficient response indicates impaired adrenal reserve, suggesting potential issues with glucocorticoid availability during sustained challenge.

Adrenal Reserve Capacity Assessment ∞ Area

Adrenal Reserve Capacity Assessment

Meaning

Clinical evaluation of the adrenal glands’ functional reserve, specifically their capacity to respond to physiological stress by releasing cortisol. This assessment quantifies the potential for HPA axis modulation under duress. It moves beyond static hormone levels to gauge dynamic endocrine responsiveness. Understanding this reserve is crucial for managing chronic fatigue and resilience.