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Adrenal HPA Axis Crosstalk

Meaning

Adrenal HPA Axis Crosstalk describes the intricate, reciprocal communication pathways between the adrenal glands and the hypothalamic-pituitary-adrenal (HPA) axis. This communication extends beyond the classical negative feedback loop, involving complex signaling that modulates the adrenal cortex’s sensitivity and steroidogenesis. The term emphasizes the multifaceted interaction where adrenal hormones, particularly cortisol and DHEA, influence pituitary and hypothalamic function. Simultaneously, centrally released factors like ACTH regulate the adrenal output. Understanding this bidirectional signaling is crucial for diagnosing and managing stress-related endocrine dysregulation.