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Adrenal Gland Sensitivity

Meaning

Adrenal Gland Sensitivity describes the responsiveness of the adrenal cortex, particularly the zona fasciculata, to its primary regulatory hormone, Adrenocorticotropic Hormone (ACTH), released by the pituitary gland. A clinically relevant definition focuses on the magnitude of the cortisol and DHEA-S output in response to a given ACTH stimulus. Optimal sensitivity ensures a balanced, timely stress response, preventing both hypo- and hyper-cortisol states. This responsiveness is a key indicator of Hypothalamic-Pituitary-Adrenal axis function.