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Adrenal Gland Functional Mass

Meaning

Adrenal Gland Functional Mass describes the total volume of adrenal cortical tissue that is biologically active and capable of synthesizing and secreting steroid hormones, particularly cortisol and DHEA. This metric reflects the intrinsic capacity of the adrenal glands to respond to HPA axis signaling and maintain hormonal homeostasis under various physiological demands. A robust functional mass indicates a greater reserve for steroidogenesis, allowing for more resilient adaptation to both acute and chronic stressors. Diminished functional mass, often due to atrophy or disease, directly compromises the body’s stress response capacity.