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Adrenal Gland Compensation

Meaning

Adrenal gland compensation represents the physiological process where the adrenal glands, primarily the cortex, adjust their steroid hormone output in response to chronic stressors or functional imbalances elsewhere in the endocrine system. This adaptive mechanism aims to maintain systemic homeostasis, particularly concerning cortisol and DHEA production. When the body faces prolonged demands, the adrenals may initially increase output, attempting to buffer the internal environment against external or internal challenges. Sustained compensation can eventually lead to a state of adrenal dysregulation, signaling a loss of optimal hormonal reserve and affecting overall well-being.