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Adrenal Fatigue Mechanistic Limits

Meaning

Adrenal Fatigue Mechanistic Limits refers to the scientific boundary defining the lack of clear, established pathophysiological mechanisms for the popular, non-medical syndrome termed “Adrenal Fatigue.” It highlights the discrepancy between subjective patient symptoms of chronic stress and the absence of verifiable, consistent endocrine failure in clinical endocrinology. The term acknowledges that while chronic stress is real, the specific biological mechanisms proposed by the “Adrenal Fatigue” model often lack rigorous scientific support and do not align with recognized adrenal disorders like Addison’s disease. This necessitates a more precise, HPA axis-focused evaluation of stress-related hormonal shifts.