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Adrenal Fatigue Mechanistic Interpretation

Meaning

The Adrenal Fatigue Mechanistic Interpretation is the scientific model explaining the proposed physiological processes underlying the non-Addisonian symptoms often grouped as “adrenal fatigue.” This interpretation focuses on chronic, low-grade stress leading to dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis, rather than outright adrenal gland failure. It specifically looks at shifts in cortisol rhythm and glucocorticoid receptor sensitivity as the primary drivers of persistent tiredness and poor stress tolerance. Clinically, this concept attempts to bridge patient-reported non-specific symptoms with measurable endocrine changes, providing a framework for targeted intervention.