Skip to main content

Adrenal Cortisol Interaction

Meaning

This term refers to the reciprocal physiological relationship between the adrenal glands and the stress hormone cortisol, where cortisol secretion influences systemic homeostasis and the adrenal function itself. The interaction is a central component of the Hypothalamic-Pituitary-Adrenal (HPA) axis, governing the body’s response to psychological and physical stressors. Maintaining this delicate balance is essential for regulating metabolism, immune response, and overall vitality. Dysregulation in this axis often manifests as clinical symptoms related to chronic stress or hormonal imbalance.