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Adrenal Axis Reserve

Meaning

Adrenal Axis Reserve quantifies the maximum functional capacity and intrinsic resilience of the Hypothalamic-Pituitary-Adrenal (HPA) axis to synthesize and secrete an adequate, timely surge of glucocorticoids, especially cortisol, in response to an acute, significant physiological or psychological stressor. A robust reserve signifies the body’s optimal ability to mount a necessary, life-sustaining adaptive response to high demand. Conversely, a depleted or insufficient reserve indicates a compromised ability to maintain systemic homeostasis under duress, a condition often investigated clinically through provocative testing.