What is the Origin of Adrenal Axis Over-Drive?

This term is rooted in the clinical interpretation of HPA axis dysfunction, particularly in response to chronic stress models. It builds upon the established physiological understanding of the stress response, where the system initially exhibits hypercortisolemia as an adaptive mechanism. The "over-drive" nomenclature denotes a pathological extension of this adaptive phase, indicating a loss of regulatory control within the feedback loop.

What is the Mechanism of Adrenal Axis Over-Drive?

The underlying mechanism involves a persistent afferent signal of stress to the hypothalamus, leading to the continuous, unmitigated release of CRH and subsequent ACTH. This chronic stimulation prevents the normal negative feedback mechanisms from adequately down-regulating adrenal cortisol production. Consequently, target tissues are exposed to supraphysiological levels of glucocorticoids, leading to receptor desensitization and downstream metabolic and immune system alterations.

Adrenal Axis Over-Drive ∞ Area

Adrenal Axis Over-Drive

Meaning

Adrenal Axis Over-Drive describes a state where the Hypothalamic-Pituitary-Adrenal (HPA) axis is chronically hyperactive, resulting in excessive, sustained secretion of stress hormones, primarily cortisol. This hyper-responsive state often arises from prolonged psychological or physiological stressors. Clinically, this hormonal imbalance can manifest as disrupted circadian cortisol rhythm and contribute to systemic inflammation and metabolic dysfunction. Managing this over-drive is key to restoring neuroendocrine balance and promoting optimal health.