Question 1

What is the Meaning of ADMA?

Accepted Answer

ADMA, an acronym for Asymmetric Dimethylarginine, is an endogenously generated amino acid derivative that functions as a critical regulatory molecule in the cardiovascular system. It is a potent, naturally occurring inhibitor of nitric oxide synthesis, a process essential for vascular health. Clinically, elevated plasma concentrations of ADMA are recognized as an independent biomarker for endothelial dysfunction and an increased risk of adverse cardiovascular events. Monitoring ADMA levels provides valuable insight into the patient's overall vascular and metabolic integrity.

Question 2

What is the Origin of ADMA?

Accepted Answer

ADMA is a byproduct of protein catabolism, specifically resulting from the methylation of L-arginine residues within various cellular proteins. After these proteins are broken down, the methylated arginine residues are released into the cytoplasm as free ADMA. This continuous intracellular process ensures a constant, low-level supply of the inhibitor into the circulation. The systemic concentration of ADMA reflects the balance between its continuous production and its subsequent metabolic elimination.

Question 3

What is the Mechanism of ADMA?

Accepted Answer

The molecule operates by acting as a competitive antagonist to the enzyme nitric oxide synthase (NOS), which normally produces the potent vasodilator nitric oxide (NO) from L-arginine. By competitively occupying the active site of NOS, ADMA reduces the bioavailability of nitric oxide, leading to vasoconstriction and impaired endothelial function. The primary clearance pathway involves the enzyme dimethylarginine dimethylaminohydrolase (DDAH), which metabolizes ADMA, largely in the liver and kidneys.

ADMA

Meaning

Origin

Mechanism

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