What is the Origin of Adiposity Hormone Axis?

This term is rooted in modern endocrinology, emerging from the discovery of key hormones secreted by adipose tissue, such as leptin, which established fat tissue not merely as an energy store but as a highly active endocrine organ. The axis concept emphasizes the feedback loops between adipocytes, the hypothalamus, and other endocrine glands. Understanding this system is central to addressing chronic metabolic and hormonal imbalances.

What is the Mechanism of Adiposity Hormone Axis?

Adipose tissue releases adipokines, notably leptin and adiponectin, which travel through the circulation to target tissues, including the hypothalamus in the brain. Leptin acts on hypothalamic receptors to signal satiety and long-term energy sufficiency, thereby decreasing food intake and increasing energy expenditure. Dysregulation, often seen as leptin resistance in states of high adiposity, disrupts this critical feedback loop, leading to persistent positive energy balance and weight gain.

Adiposity Hormone Axis ∞ Area

Adiposity Hormone Axis

Meaning

The Adiposity Hormone Axis refers to the complex, bidirectional neuroendocrine communication network that governs energy balance, appetite regulation, and fat mass distribution through the signaling of adipocyte-derived hormones. This axis integrates peripheral metabolic status with central nervous system control, influencing long-term body weight set point and metabolic health. Clinical assessment of this axis provides insight into the underlying hormonal drivers of weight dysregulation and metabolic syndrome.