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Adiposity Driven Resistance

Meaning

Adiposity Driven Resistance describes a physiological state where excessive or dysfunctional adipose tissue, commonly known as body fat, actively contributes to a reduced sensitivity in peripheral tissues to metabolic hormones like insulin. This chronic condition is not merely a passive storage issue; rather, it is characterized by the fat cells themselves releasing adipokines and inflammatory mediators that interfere with normal cellular signaling. The resulting hormonal insensitivity impairs glucose uptake and utilization, fundamentally altering systemic energy balance and contributing to cardiometabolic risk.