Skip to main content

Adipose Tissue Signaling Disruption

Meaning

Adipose tissue signaling disruption is a pathological state characterized by impaired or aberrant communication between body fat (adipose tissue) and distant metabolic organs, including the liver, muscle, and brain. This dysfunction involves a dysregulated secretion of critical adipokines, such as leptin and adiponectin, leading to a breakdown in systemic metabolic harmony. Clinically, this disruption is a key underlying contributor to chronic low-grade inflammation, systemic insulin resistance, and the unhealthy accumulation of visceral fat. Understanding this failure in endocrine communication is critical for addressing complex cardiometabolic risk profiles.