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Adipose Tissue Insulin Resistance

Meaning

Adipose tissue insulin resistance is a physiological state where fat cells, or adipocytes, exhibit a diminished responsiveness to the signaling action of insulin. This reduced sensitivity impairs the ability of adipose tissue to suppress lipolysis, leading to an excessive release of free fatty acids into the circulation. This metabolic dysfunction is a crucial precursor to systemic insulin resistance and often contributes significantly to dyslipidemia and ectopic fat deposition in other organs. Clinical assessment of this condition is vital for understanding the progression of metabolic syndrome and type 2 diabetes risk.