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Adipose Tissue Glucocorticoid Sensitivity

Meaning

Adipose Tissue Glucocorticoid Sensitivity is the degree to which fat cells, or adipocytes, respond to the signaling of glucocorticoid hormones, primarily the stress hormone cortisol. This cellular responsiveness is a critical determinant of how cortisol influences both the storage and breakdown (lipolysis) of fat within the body’s various depots. Alterations in this sensitivity are central to understanding the link between chronic stress and adverse body composition changes. This concept helps explain why some individuals preferentially accumulate fat in metabolically unhealthy visceral areas.