What is the Meaning of Adipose Tissue Dysfunction?

A pathological state where adipose tissue, or body fat, loses its healthy endocrine and metabolic function, moving beyond simple energy storage. This dysfunction is characterized by chronic low-grade inflammation, impaired adipokine secretion—such as leptin and adiponectin—and reduced capacity for safe lipid storage. Clinically, this metabolic shift is a major driver of insulin resistance and systemic metabolic syndrome, significantly impacting overall hormonal balance. The compromised tissue actively contributes to a pro-inflammatory systemic environment.

What is the Origin of Adipose Tissue Dysfunction?

The concept stems from modern endocrinology and metabolism research, recognizing fat tissue as an active endocrine organ rather than a passive reservoir. 'Adipose' is derived from the Latin adeps meaning fat, and 'dysfunction' refers to abnormal or impaired operation. This understanding represents a paradigm shift in how clinicians view the role of body fat in systemic health.

What is the Mechanism of Adipose Tissue Dysfunction?

Adipose tissue dysfunction involves the hypertrophy of adipocytes and subsequent macrophage infiltration, initiating a pro-inflammatory state. This process leads to the ectopic deposition of lipids in organs like the liver and muscle, profoundly impairing insulin sensitivity. The resulting altered adipokine profile, including increased pro-inflammatory cytokines, directly interferes with insulin signaling and systemic hormonal homeostasis. This metabolic crosstalk creates a vicious cycle of inflammation and endocrine disruption.

Adipose Tissue Dysfunction ∞ Area

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Fat Is Not Just Storage

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∞ Cellular Signaling
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∞ Adipose Tissue
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∞ Adipose Tissue
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PCOS symptoms re-emerge without lifestyle changes because they are the tools that directly manage the condition's core hormonal imbalances.

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Adipose Tissue Dysfunction

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