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Adipose Tissue Clock

Meaning

The Adipose Tissue Clock is the intrinsic, self-sustaining circadian rhythmicity present within adipocytes and the surrounding adipose tissue microenvironment. This peripheral clock governs the temporal organization of key metabolic processes, including lipogenesis, lipolysis, and the secretion of various adipokines throughout the 24-hour cycle. Dysregulation of this tissue-specific biological clock is strongly linked to metabolic dysfunction, contributing to insulin resistance and obesity-related hormonal imbalances. Maintaining synchrony between the central pacemaker and this peripheral tissue clock is crucial for systemic metabolic homeostasis.