Adipose mobilization dynamics describes the highly regulated physiological process concerning the release and transport of stored triglycerides from adipocytes into the circulation as free fatty acids and glycerol. This process is essential for providing energy substrates to other tissues during periods of fasting or increased energy demand. The efficiency and control of this mobilization are key indicators of hormonal balance and metabolic flexibility.
Origin
The term combines adipose (referring to fat tissue), mobilization (the act of making something movable), and dynamics (the study of forces that produce motion). Its clinical context originates from endocrinology and nutritional science, focusing on how the body’s energy reserves are accessed and utilized under the influence of various lipolytic and anti-lipolytic hormones.
Mechanism
Lipolysis, the core mechanism, is initiated by hormonal signals such as catecholamines and growth hormone, which activate hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) within the adipocyte. These enzymes sequentially hydrolyze triglycerides into fatty acids and glycerol. The released free fatty acids are then bound to albumin in the bloodstream for transport to metabolically active tissues, where they undergo beta-oxidation for energy production.
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