What is the Origin of Adiponectin Secretion?

The term combines "adiponectin," a protein derived from adipo- (fat) and nectin (to bind/connect), with "secretion," the physiological process of releasing a substance. It belongs to the domain of endocrinology and adipose tissue biology. Adiponectin was first identified as a major protein secreted by adipocytes, linking fat tissue directly to systemic metabolism.

What is the Mechanism of Adiponectin Secretion?

Adiponectin secretion is inversely correlated with adipocyte size; smaller, healthier fat cells release more of the hormone. Once in the bloodstream, it activates AMPK and PPAR-alpha pathways in tissues like the liver and muscle. This activation enhances insulin signaling, reduces hepatic glucose production, and increases the breakdown of fatty acids, ultimately exerting potent anti-inflammatory and anti-atherogenic effects.

Adiponectin Secretion ∞ Area

Adiponectin Secretion

Meaning

The process by which adiponectin, an adipokine hormone, is released from adipose tissue, primarily white fat cells, into the systemic circulation. This release is crucial for regulating metabolic processes, including glucose homeostasis and fatty acid catabolism. Maintaining optimal adiponectin secretion levels is a key indicator of healthy metabolic function and insulin sensitivity.