What is the Origin of Adipokine Signaling Pathways?

The term is a synthesis of "adipokine," derived from adipo- (fat) and -kine (signal or movement), combined with the foundational concept of "signaling pathways" from cellular biology. This terminology arose from the scientific recognition that adipose tissue functions actively as a dynamic endocrine organ, rather than simply a passive energy storage site.

What is the Mechanism of Adipokine Signaling Pathways?

The mechanism involves the release of adipokines, such as leptin and adiponectin, into the circulation where they bind to specific receptors on target cells in peripheral tissues like muscle, liver, and the central nervous system. This receptor-ligand interaction initiates intracellular cascades, often involving phosphorylation events, which ultimately modulate gene expression and cellular function to influence systemic metabolic balance.

Adipokine Signaling Pathways

Meaning

Adipokine Signaling Pathways are the intricate communication networks initiated by adipokines, which are bioactive signaling molecules secreted by adipose tissue, or body fat. These pathways govern fundamental physiological processes, including the regulation of energy homeostasis, modulation of insulin sensitivity, and control of systemic inflammation. Understanding these complex endocrine signals is clinically essential for managing metabolic health and mitigating cardiovascular risk.

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