What is the Origin of Adipokine Signaling Pathology?

The term combines "adipokine," derived from adipo- (fat) and kine (movement/signal), with "signaling," referring to cell communication, and "pathology," the study of disease. This concept emerged from the recognition in endocrinology that adipose tissue is an active endocrine organ, not merely an inert reservoir. Understanding the pathological signaling from fat tissue is a relatively modern development in metabolic health science.

What is the Mechanism of Adipokine Signaling Pathology?

Pathological adipokine signaling involves the excessive or deficient secretion of key regulatory peptides by dysfunctional adipocytes, particularly in visceral fat accumulation. For example, increased pro-inflammatory adipokines, like resistin and certain interleukins, can impair insulin receptor sensitivity in peripheral tissues. This altered endocrine messaging subsequently contributes to chronic low-grade inflammation and the progression of cardiometabolic disorders.

Adipokine Signaling Pathology ∞ Area

Adipokine Signaling Pathology

Meaning

The disruption or dysfunction in the communication pathways mediated by adipokines, which are bioactive molecules secreted by adipose (fat) tissue. This pathology involves an imbalance in the production and release of these hormones, such as leptin and adiponectin, leading to systemic metabolic and inflammatory disturbances. Clinically, this state is often associated with conditions like insulin resistance, type 2 diabetes, and cardiovascular disease, highlighting the critical endocrine role of fat tissue beyond energy storage.