What is the Origin of Adipokine Signaling Disruption?

The term combines Adipokine (hormones/cytokines secreted by fat tissue), Signaling (the process of communication between cells), and Disruption (a disturbance or interruption). Its foundation lies in endocrinology and immunometabolism, recognizing adipose tissue as a highly active endocrine organ. This recognition redefined fat tissue's role from simple storage to complex hormonal regulation.

What is the Mechanism of Adipokine Signaling Disruption?

Disruption can occur at several points, including altered adipokine secretion rates, impaired receptor binding affinity on target cells, or post-receptor signaling pathway failure. For example, excess adipose tissue can lead to dysregulated leptin and adiponectin levels, which subsequently interferes with hypothalamic and peripheral tissue sensitivity. This malfunction perpetuates a cycle of chronic low-grade inflammation and metabolic resistance, further exacerbating hormonal imbalances.

Adipokine Signaling Disruption ∞ Area

Adipokine Signaling Disruption

Meaning

This refers to the impairment or interference with the normal communication pathways mediated by adipokines, which are bioactive molecules secreted by adipose tissue. Adipokine signaling is central to metabolic regulation, inflammation, and insulin sensitivity throughout the body. Disruptions can lead to systemic metabolic dysfunction, a common factor in obesity and related hormonal imbalances. Clinically, this disruption is a major contributor to the pathology of insulin resistance.