What is the Origin of Adipokine Profile Shifting?

The term combines 'adipokine', derived from 'adipo-' (fat) and '-kine' (movement/signal), with 'profile shifting', emphasizing the change in the collective secretory pattern of these hormones. It originates from the field of endocrinology and metabolic research, recognizing adipose tissue as an active endocrine organ, not just an energy store. This concept became central to understanding the link between obesity, chronic inflammation, and hormonal dysregulation.

What is the Mechanism of Adipokine Profile Shifting?

Adipokine profile shifting is primarily driven by changes in adipocyte size and local hypoxia within expanding adipose tissue. As fat cells enlarge, they reduce the secretion of beneficial adipokines like adiponectin while increasing pro-inflammatory cytokines such as leptin and resistin. This altered hormonal output influences systemic insulin sensitivity, vascular function, and chronic low-grade inflammation throughout the body.

Adipokine Profile Shifting ∞ Area

Adipokine Profile Shifting

Meaning

The dynamic change in the pattern and concentration of adipokines, which are signaling molecules secreted by adipose tissue (body fat). This shift reflects alterations in metabolic health and inflammatory status, moving from a beneficial, anti-inflammatory profile to a detrimental, pro-inflammatory one. Clinically, monitoring this profile provides critical insight into the endocrine function of fat tissue, extending beyond simple body mass index measurements.