What is the Origin of Adipokine Network?

The term is a compound of "adipo-" derived from the Latin adeps meaning fat, and "-kine" from the Greek kīneîn meaning to move or actuate, thus denoting a signaling molecule originating from fat tissue. This concept emerged from groundbreaking research that redefined adipose tissue, moving it from a passive energy storage depot to a dynamic and active endocrine organ. The recognition of adipokines like leptin and adiponectin fundamentally changed our understanding of energy homeostasis.

What is the Mechanism of Adipokine Network?

Adipokines, which include hormones such as leptin and adiponectin, along with various inflammatory interleukins, are released directly into the systemic circulation to exert autocrine, paracrine, and endocrine effects. Functionally, they modulate insulin sensitivity in peripheral tissues, regulate appetite and overall energy homeostasis, and significantly influence the state of chronic low-grade inflammation. Dysregulation within this network is recognized as a key physiological driver in the progression of metabolic syndrome, type 2 diabetes, and related hormonal imbalances.

Adipokine Network ∞ Area

Adipokine Network

Meaning

The Adipokine Network represents the complex system of signaling molecules, known as adipokines, that are secreted by adipose tissue, or body fat. This network is fundamentally endocrine in nature, acting as a crucial communication hub between fat cells and distant organs like the liver, muscle, and brain. These secreted hormones and peptides are powerful modulators of systemic metabolic and inflammatory processes throughout the body.