Clinical strategy focused on regulating the metabolic and endocrine roles of fat cells, or adipocytes, beyond simple energy storage. This comprehensive approach seeks to optimize adipokine secretion, which includes vital hormones like leptin and adiponectin, for systemic health benefits. Effective management aims to prevent or mitigate the pathological consequences of dysfunctional adipose tissue, such as chronic low-grade inflammation and insulin resistance.
Origin
The concept arises from endocrinology and cellular biology, combining “adipocyte” (fat cell) with the clinical practice of “management” to reflect a proactive, targeted intervention in metabolic health. This lexicon term highlights the shift from viewing fat merely as inert storage to recognizing it as a dynamic, hormone-producing endocrine organ.
Mechanism
Intervention strategies typically modulate cellular pathways that control adipogenesis, lipolysis, and cytokine release within the adipose tissue. By influencing key nuclear receptors and transcription factors, the goal is to maintain a healthy, metabolically active phenotype in adipocytes. This balanced function ensures appropriate lipid handling and a beneficial systemic hormonal profile, directly supporting glucose homeostasis and cardiovascular health.
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