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Adenosine Signaling Clearance

Meaning

The physiological process of efficiently removing or inactivating adenosine from the extracellular space, particularly within the central nervous system. This clearance is crucial for regulating the balance between sleep-promoting, adenosine accumulation, and wakefulness-promoting, adenosine removal, states. Effective clearance supports optimal neuronal function and prevents excessive suppression of arousal pathways, which is vital for sustained daytime energy.