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Adenosine Signaling

Meaning

A crucial purinergic signaling pathway mediated by the nucleoside adenosine, which acts as an endogenous neuromodulator and homeostatic regulator in nearly all tissues. It plays a significant role in energy balance, sleep-wake cycles, and cardiovascular function by binding to specific G-protein coupled receptors. In the context of hormonal health, this signaling cascade intricately influences metabolic rate and the hypothalamic-pituitary-adrenal (HPA) axis activity. Modulating adenosine activity is a therapeutic target for conditions related to energy expenditure and stress response.