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Adenosine Receptor Antagonism Reversal

Meaning

The physiological process of overcoming the blocking effect of an antagonist molecule on adenosine receptors, restoring the natural signaling cascade. Adenosine is a crucial neuromodulator that typically promotes restfulness and vasodilation by binding to its receptors, primarily A1 and A2A. Reversal of antagonism is essential for mitigating unwanted side effects and re-establishing a balanced neuroendocrine state. This mechanism is central to understanding the acute and chronic effects of common substances like caffeine within the human system.