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Adenosine Metabolic Clearance

Meaning

The physiological process describing the rate and efficiency with which the neuromodulator adenosine is removed from the extracellular space and metabolized within the body. This clearance is crucial for regulating the sleep-wake cycle, as accumulating adenosine drives sleep pressure, while efficient removal promotes wakefulness. Proper metabolic clearance ensures appropriate signaling for cellular energy status and neurotransmission across various tissues, directly impacting systemic energy balance and cognitive function.