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Adenosine Clearance Strategy

Meaning

Adenosine Clearance Strategy refers to the systematic process of managing the accumulation of adenosine, a potent nucleoside that acts as a homeostatic sleep pressure signal, to sustain alertness and optimize cognitive performance. This strategy involves either promoting the body’s natural enzymatic breakdown of adenosine or utilizing competitive antagonists to block its inhibitory action on neuronal receptors. Clinical applications are focused on extending periods of high-quality wakefulness and mitigating the debilitating effects of daytime sleepiness.