Question 1

What is the Meaning of ADD1/SREBP1c?

Accepted Answer

ADD1/SREBP1c refers to a specific protein known as Adipocyte Determination and Differentiation Factor 1, which is identical to Sterol Regulatory Element-Binding Protein 1c. This transcription factor is a master regulator of lipid homeostasis and fatty acid synthesis within the body. In the context of metabolic and hormonal health, its activity profoundly influences fat storage and energy balance.

Question 2

What is the Origin of ADD1/SREBP1c?

Accepted Answer

The term's origin lies in molecular biology and metabolic research, where SREBP1c is a member of the SREBP family of transcription factors, named for their ability to bind to Sterol Regulatory Elements in gene promoters. The 'c' denotes the specific isoform predominantly involved in lipogenesis. It serves as a critical link between nutrient sensing and genetic expression for fat production.

Question 3

What is the Mechanism of ADD1/SREBP1c?

Accepted Answer

SREBP1c is synthesized as a precursor protein tethered to the endoplasmic reticulum membrane; when activated by insulin or nutrient sufficiency, it is cleaved to release the active N-terminal domain. This mature transcription factor then translocates to the nucleus where it binds to DNA regulatory elements, stimulating the transcription of genes encoding lipogenic enzymes. The resulting increase in fatty acid and triglyceride synthesis connects this pathway directly to metabolic syndrome and liver health.

ADD1/SREBP1c

Meaning

Origin

Mechanism

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