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Adaptive Receptor Changes

Meaning

This term describes the dynamic modification of the number or sensitivity of hormone receptors on target cells in response to fluctuating hormonal signals. These cellular adjustments, which include upregulation and downregulation, are crucial for maintaining endocrine homeostasis and tissue responsiveness. When hormone concentrations are consistently high, cells may decrease receptor density to prevent overstimulation, a process known as desensitization. Conversely, low hormone levels can trigger an increase in receptor expression to maximize the cellular response to the limited signal.