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ACTN3 Gene Expression

Meaning

This refers to the process by which the information encoded in the ACTN3 gene is converted into the alpha-actinin-3 protein, primarily found in fast-twitch skeletal muscle fibers. Variations in this gene’s expression, particularly the presence or absence of the R577X polymorphism, significantly influence muscle performance phenotypes, notably power and sprint capabilities. Understanding an individual’s ACTN3 expression is crucial for optimizing exercise protocols and managing expectations regarding muscle physiology. This genetic insight provides a molecular foundation for differences in athletic potential and muscle response to training stimuli.