Skip to main content

Active Metabolite Fraction

Meaning

This term precisely denotes the percentage of a parent compound, such as a prohormone or pharmaceutical agent, that is successfully converted into its biologically active, functional metabolite within the human body. Understanding this fraction is critical for determining the true systemic impact and efficacy of a therapeutic dose, moving beyond simple total compound concentration. A higher fraction suggests more efficient conversion into the form that interacts with target receptors or enzymes. Clinical translation relies heavily on this data to optimize dosing regimens for maximum therapeutic benefit.