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ACTH Dynamics

Meaning

ACTH Dynamics refers to the complex patterns and temporal variations in the secretion and action of Adrenocorticotropic Hormone, a critical pituitary hormone. This dynamic profile includes the characteristic pulsatile release and the pronounced diurnal rhythm, where ACTH levels are typically highest in the morning and lowest at night. Assessing these dynamics provides crucial insight into the functional status of the hypothalamic-pituitary-adrenal (HPA) axis, which governs the body’s stress response and cortisol production. Deviations from the expected rhythmic patterns can signal underlying endocrine dysfunction, impacting overall hormonal balance and systemic well-being.