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Acetylcholine Estrogen Link

Meaning

This term denotes the documented neuroendocrine relationship where the steroid hormone estrogen significantly modulates the function and synthesis of the neurotransmitter acetylcholine within the central nervous system. This hormonal interplay is particularly crucial in brain regions associated with memory, attention, and cognitive processing. Fluctuations in estrogen levels, such as those occurring during menopause, directly impact cholinergic signaling, influencing cognitive performance and mood stability. Clinically, understanding this link informs therapeutic strategies aimed at maintaining neurocognitive health across the lifespan.