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Acetyl-CoA Histone Acetylation

Meaning

This term describes a critical post-translational modification where an acetyl group, derived from Acetyl-CoA, is enzymatically transferred onto lysine residues of histone proteins. Histone acetylation is a fundamental epigenetic mark that typically promotes a more open chromatin structure, thereby increasing gene transcription. In the context of hormonal health, this process links cellular metabolic status, specifically the availability of Acetyl-CoA, directly to gene expression patterns that govern endocrine function and cellular longevity. This molecular event is central to regulating the expression of genes involved in energy homeostasis and stress response pathways.