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Acetaldehyde Toxicity

Meaning

The clinical state arising from the systemic accumulation of acetaldehyde, a highly reactive and toxic metabolite primarily produced during ethanol metabolism in the liver. This buildup overwhelms the body’s detoxification capacity, leading to cellular damage, inflammation, and physiological distress. In the context of hormonal health, this toxicity can negatively impact endocrine function, potentially disrupting hormone synthesis and signaling pathways. Chronic exposure is linked to mitochondrial dysfunction, a core issue in accelerated biological aging.