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ACE2 Pathway

Meaning

The Angiotensin-Converting Enzyme 2 (ACE2) pathway is a crucial physiological cascade primarily recognized for its role in regulating the Renin-Angiotensin-Aldosterone System (RAAS). This enzyme acts as a counter-regulator to ACE, primarily by cleaving Angiotensin II into Angiotensin 1-7, a peptide associated with vasodilation and anti-inflammatory effects. In the context of hormonal health, the pathway is intrinsically linked to cardiovascular function, blood pressure regulation, and systemic inflammation, all of which are significantly influenced by sex hormones like estrogen and testosterone. Understanding this balance is vital for assessing long-term cardiometabolic wellness.