Question 1

What is the Meaning of ACE I/D Polymorphism?

Accepted Answer

The ACE I/D Polymorphism represents a common genetic variation within the Angiotensin-Converting Enzyme gene, which is a critical component of the Renin-Angiotensin-Aldosterone System. This variation is categorized by either the insertion (I) or deletion (D) of a 287 base pair segment in the gene's intron. The presence of this polymorphism can significantly influence the circulating concentration of the ACE enzyme in an individual. Clinically, this genetic marker is often investigated to assess a patient's predisposition to cardiovascular and metabolic conditions.

Question 2

What is the Origin of ACE I/D Polymorphism?

Accepted Answer

This polymorphism's origin lies within the Angiotensin-Converting Enzyme gene, a key regulator of blood pressure and fluid balance throughout the body. The insertion or deletion of the non-coding Alu repeat sequence in intron 16 of the gene defines the three primary genotypes: II, ID, and DD. Research has consistently demonstrated that the D allele correlates with higher plasma ACE levels, while the I allele is associated with lower levels. This natural genetic variation has become a foundational subject in pharmacogenomics and risk stratification.

Question 3

What is the Mechanism of ACE I/D Polymorphism?

Accepted Answer

The deletion (D) allele results in increased transcription and production of the ACE enzyme, subsequently raising the systemic levels of Angiotensin II, a potent vasoconstrictor. This heightened Angiotensin II activity influences fluid homeostasis, blood pressure, and vascular tone. Moreover, the polymorphism is implicated in metabolic health, as the D allele has been linked to increased insulin sensitivity in some populations, while the II genotype may offer a degree of protection against diabetic nephropathy. The interplay between these genetic factors and the endocrine system is a complex yet crucial determinant of overall cardiometabolic wellness.

ACE I/D Polymorphism

Meaning

Origin

Mechanism

Can Genetic Predispositions Influence Individual Responses to Dietary Fluid Management Strategies?

Provided by the clinical team
at 4Ever Young Miami Dadeland

-15% ∞ HRTIO15

Your protocol begins with a conversation.

Visit

Schedule Appointment

About

Med & Wellness

4Ever Young Miami Dadeland

Communication

+1 786-529-6686

Email Us

Opening Hours