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Accelerated Clearance

Meaning

Accelerated Clearance refers to the phenomenon in which a substance, such as an administered hormone or medication, is removed from the systemic circulation at a rate significantly faster than the expected physiological half-life. This increased rate of elimination leads to a rapid reduction in the effective concentration of the compound within the bloodstream. Clinically, this necessitates higher or more frequent dosing to maintain therapeutic hormone levels. Understanding this pharmacokinetic deviation is crucial for effective hormonal health management.