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9p21 Locus

Meaning

The 9p21 locus refers to a specific, non-coding region on the short arm of chromosome 9, which is recognized as one of the most significant genetic determinants for coronary artery disease in diverse populations. This region contains the genes CDKN2A and CDKN2B, which encode inhibitors of the cell cycle and play a pivotal role in cellular senescence. Identifying variations within this locus allows clinicians to assess a patient’s inherited susceptibility to adverse cardiovascular events. This genetic area acts as a crucial barometer of long-term vascular health and cellular aging.